Human APOBEC3H protein (Recombinant) (N-His) (STJP016227)

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STJP016227
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Short Description :Recombinant-Human APOBEC3H-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:APOBEC3H
Gene ID:164668
Uniprot ID:ABC3H_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Met1-Val200
Post Translational Modifications (Microbial infection) Following infection by some HIV-1 strains, such as isolate BRU/LAI, can be ubiquitinated by a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex) hijacked by the HIV-1 Vif protein, leading to its degradation. Ubiquitination by the ECS complex is however less efficent compared to APOBEC3G or APOBEC3G.
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Protein Name Dna Dc->Du-Editing Enzyme Apobec-3h
Apobec-Related Protein 10
Arp-10
Apolipoprotein B Mrna-Editing Enzyme Catalytic Polypeptide-Like 3h
A3h
Database Links Reactome: R-HSA-72200
Reactome: R-HSA-75094
Cellular Localisation Cytoplasm
Nucleus
P-Body
Haplotype 1 Is Distributed In Both The Nucleus And Cytoplasm
Whereas Haplotype 2 Is Predominantly Cytoplasmic
Alternative Protein Names Dna Dc->Du-Editing Enzyme Apobec-3h protein
Apobec-Related Protein 10 protein
Arp-10 protein
Apolipoprotein B Mrna-Editing Enzyme Catalytic Polypeptide-Like 3h protein
A3h protein
APOBEC3H protein

Information sourced from Uniprot.org

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