| Post Translational Modifications | Phosphorylated on serine residues. Pyrophosphorylation by 5-diphosphoinositol pentakisphosphate (5-IP7) impairs interaction with KIF3A. Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue. |
| Function | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
| Protein Name | Ap-3 Complex Subunit Beta-1Adaptor Protein Complex Ap-3 Subunit Beta-1Adaptor-Related Protein Complex 3 Subunit Beta-1Beta-3a-AdaptinClathrin Assembly Protein Complex 3 Beta-1 Large Chain |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-6802952 |
| Cellular Localisation | Cytoplasmic VesicleClathrin-Coated Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideGolgi ApparatusComponent Of The Coat Surrounding The Cytoplasmic Face Of Coated Vesicles Located At The Golgi Complex |
| Alternative Protein Names | Ap-3 Complex Subunit Beta-1 proteinAdaptor Protein Complex Ap-3 Subunit Beta-1 proteinAdaptor-Related Protein Complex 3 Subunit Beta-1 proteinBeta-3a-Adaptin proteinClathrin Assembly Protein Complex 3 Beta-1 Large Chain proteinAP3B1 proteinADTB3A protein |
Information sourced from Uniprot.org
