| Post Translational Modifications | Palmitoylated. |
| Function | Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function.negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex. |
| Protein Name | Ap-1 Complex-Associated Regulatory Protein2c18Adaptor-Related Protein Complex 1-Associated Regulatory ProteinGamma-1-Adaptin Brefeldin A Resistance ProteinGbarGamma-BarGamma-A1-Adaptin And Kinesin InteractorGadkin |
| Database Links | |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkLate EndosomeEarly EndosomeLocalizes To The Juxta-Nuclear Golgi Region And To Tubular Structures Throughout The CytoplasmWhich Are Highly Mobile And Cycle Between The Juxta-Nuclear Area And The Cell Periphery |
| Alternative Protein Names | Ap-1 Complex-Associated Regulatory Protein protein2c18 proteinAdaptor-Related Protein Complex 1-Associated Regulatory Protein proteinGamma-1-Adaptin Brefeldin A Resistance Protein proteinGbar proteinGamma-Bar proteinGamma-A1-Adaptin And Kinesin Interactor proteinGadkin proteinAP1AR proteinC4orf16 proteinPRO0971 protein |
Information sourced from Uniprot.org
