Human Annexin A2/ANXA2 protein (Recombinant) (His-Tag) (STJP016609)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Annexin A2/ANXA2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANXA2 |
| Gene ID | 302 |
| Uniprot ID | ANXA2_HUMAN |
| Accession Number | NP_001002857.1 |
| Immunogen | Human |
| Immunogen Region | 1-339aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated. |
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation. Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis. (Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. |
| Protein Name | Annexin A2Annexin IiAnnexin-2Calpactin I Heavy ChainCalpactin-1 Heavy ChainChromobindin-8Lipocortin IiPlacental Anticoagulant Protein IvPap-IvProtein IP36 |
| Database Links | Reactome: R-HSA-445355Reactome: R-HSA-6798695Reactome: R-HSA-75205Reactome: R-HSA-8950505Reactome: R-HSA-9860927 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMelanosomeIn The Lamina Beneath The Plasma MembraneIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvTranslocated From The Cytoplasm To The Cell Surface Through A Golgi-Independent Mechanism |
| Alternative Protein Names | Annexin A2 proteinAnnexin Ii proteinAnnexin-2 proteinCalpactin I Heavy Chain proteinCalpactin-1 Heavy Chain proteinChromobindin-8 proteinLipocortin Ii proteinPlacental Anticoagulant Protein Iv proteinPap-Iv proteinProtein I proteinP36 proteinANXA2 proteinANX2 proteinANX2L4 proteinCAL1H proteinLPC2D protein |
Information sourced from Uniprot.org