Human Annexin A13/ANXA13 protein (Recombinant) (His-Tag) (STJP017150)

SKU:
STJP017150
€161.40 - €886.20
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Short Description :Recombinant-Human Annexin A13/ANXA13-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% Glycerol, 0.1M NaCl, 1mM EDTA
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:ANXA13
Gene ID:312
Uniprot ID:ANX13_HUMAN
Accession Number:NP_004297
Immunogen:Human
Immunogen Region:1-316aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EVLCTRTNKE IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD AGEGRWGTDE LAFNEVLAKR SYKQLRAT
Tissue Specificity Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum.
Function Isoform A: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. Isoform B: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.
Protein Name Annexin A13
Annexin Xiii
Annexin-13
Intestine-Specific Annexin
Isa
Database Links
Cellular Localisation Apical Cell Membrane
Cell Membrane
Lipid-Anchor
Cytoplasmic Vesicle
Myristoylation Anchors The Protein To The Membrane
But The Protein Also Displays Calcium-Dependent
Reversible Binding To Lipid Membranes
Associated With The Plasma Membrane Of Undifferentiated
Proliferating Crypt Epithelial Cells As Well As Differentiated Villus Enterocytes
Alternative Protein Names Annexin A13 protein
Annexin Xiii protein
Annexin-13 protein
Intestine-Specific Annexin protein
Isa protein
ANXA13 protein
ANX13 protein

Information sourced from Uniprot.org