Human AMOT protein (Recombinant) (N-His) (STJP008168)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AMOT-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | AMOT |
| Gene ID | 154796 |
| Uniprot ID | AMOT_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr650-Glu772 |
Additional Info
| Post Translational Modifications | Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation. |
| Function | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions. |
| Protein Name | Angiomotin |
| Database Links | Reactome: R-HSA-2028269 Q4VCS5-1Reactome: R-HSA-9762292 Q4VCS5-2 |
| Cellular Localisation | Cell JunctionTight JunctionLocalized On The Cell SurfaceMay Act As A Transmembrane Protein |
| Alternative Protein Names | Angiomotin proteinAMOT proteinKIAA1071 protein |
Information sourced from Uniprot.org