Human Amnionless protein (Recombinant) (His-Tag) (STJP017973)

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STJP017973
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Amnionless-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 1mM DTT
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: AMN
Gene ID: 81693
Uniprot ID: AMNLS_HUMAN
Immunogen Region: 20-357aa
Accession Number: NP_112205
Immunogen: Human
Immunogen Sequence: VSKLWVP NTDFDVAANW SQNRTPCAGG AVEFPADKMV SVLVQEGHAV SDMLLPLDGE LVLASGAGFG VSDVGSHLDC GAGEPAVFRD SDRFSWHDPH LWRSGDEAPG LFFVDAERVP CRHDDVFFPP SASFRVGLGP GASPVRVRSI SALGRTFTRD EDLAVFLASR AGRLRFHGPG ALSVGPEDCA DPSGCVCGNA EAQPWI
Tissue Specificity Detected in proximal tubules in the kidney cortex (at protein level). Long isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and peripheral blood leukocytes.
Post Translational Modifications N-glycosylated. A soluble form arises by proteolytic removal of the membrane anchor.
Function Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12. Required for normal CUBN-mediated protein transport in the kidney (Probable).
Protein Name Protein Amnionless Cleaved Into - Soluble Protein Amnionless
Database Links Reactome: R-HSA-3359462
Reactome: R-HSA-3359463
Reactome: R-HSA-8964011
Reactome: R-HSA-9758881
Cellular Localisation Isoform 1: Apical Cell Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Endosome Membrane
Membrane
Coated Pit
Soluble Protein Amnionless: Secreted
Alternative Protein Names Protein Amnionless Cleaved Into - Soluble Protein Amnionless protein
AMN protein
UNQ513 protein
PRO1028 protein

Information sourced from Uniprot.org

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