| Host: | Mammalian Cells |
| Applications: | ELISA/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Human AMIGO2-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by the ability of the Immobilised protein to support the adhesion of bovine corneal endothelial cells (BCE C/D‑1b). The ED50 for this effect is 0.5-2.0 Mu g/mL. |
| Gene Symbol: | AMIGO2 |
| Gene ID: | 347902 |
| Uniprot ID: | AMGO2_HUMAN |
| Immunogen Region: | Gly39-His393 |
| Immunogen: | Homo sapiens (Human) |
| Function | Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. |
| Protein Name | Amphoterin-Induced Protein 2Amigo-2Alivin-1Differentially Expressed In Gastric AdenocarcinomasDega |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013423 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinNucleusAssociated With Nucleus As Well As Plasma MembraneRestricted To Somata Of Cerebellar As Well As Hippocampal Neurons |
| Alternative Protein Names | Amphoterin-Induced Protein 2 proteinAmigo-2 proteinAlivin-1 proteinDifferentially Expressed In Gastric Adenocarcinomas proteinDega proteinAMIGO2 proteinALI1 protein |
Information sourced from Uniprot.org