Human AMD1 protein (Recombinant) (His-Tag) (STJP017715)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human AMD1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AMD1 |
| Gene ID | 262 |
| Uniprot ID | DCAM_HUMAN |
| Accession Number | NP_001625 |
| Immunogen | Human |
| Immunogen Region | 68-334aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. |
| Function | Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. |
| Protein Name | S-Adenosylmethionine Decarboxylase ProenzymeAdometdcSamdc Cleaved Into - S-Adenosylmethionine Decarboxylase Alpha Chain - S-Adenosylmethionine Decarboxylase Beta Chain |
| Database Links | Reactome: R-HSA-351202 |
| Cellular Localisation | |
| Alternative Protein Names | S-Adenosylmethionine Decarboxylase Proenzyme proteinAdometdc proteinSamdc Cleaved Into - S-Adenosylmethionine Decarboxylase Alpha Chain - S-Adenosylmethionine Decarboxylase Beta Chain proteinAMD1 proteinAMD protein |
Information sourced from Uniprot.org