Human ALOX12B protein (Recombinant) (N-His) (STJP003350)

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STJP003350
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ALOX12B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ALOX12B
Gene ID: 242
Uniprot ID: LX12B_HUMAN
Immunogen Region: Leu479-Ile701
Immunogen: Homo sapiens (Human)
Function Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.
Protein Name Arachidonate 12-Lipoxygenase - 12r-Type
12r-Lox
12r-Lipoxygenase
Epidermis-Type Lipoxygenase 12
Database Links Reactome: R-HSA-2142712
Cellular Localisation Cytoplasm
Perinuclear Region
Alternative Protein Names Arachidonate 12-Lipoxygenase - 12r-Type protein
12r-Lox protein
12r-Lipoxygenase protein
Epidermis-Type Lipoxygenase 12 protein
ALOX12B protein

Information sourced from Uniprot.org

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