Human ALKBH7 protein (Recombinant) (N-His) (STJP009044)

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STJP009044
£328.50 - £1,437.50
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Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ALKBH7-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ALKBH7
Gene ID: 84266
Uniprot ID: ALKB7_HUMAN
Immunogen Region: Ser16-Cys221
Immunogen: Homo sapiens (Human)
Function May function as protein hydroxylase.can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.
Protein Name Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 7 - Mitochondrial
Alkylated Dna Repair Protein Alkb Homolog 7
Spermatogenesis Cell Proliferation-Related Protein
Spermatogenesis-Associated Protein 11
Cellular Localisation Mitochondrion Matrix
Alternative Protein Names Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 7 - Mitochondrial protein
Alkylated Dna Repair Protein Alkb Homolog 7 protein
Spermatogenesis Cell Proliferation-Related Protein protein
Spermatogenesis-Associated Protein 11 protein
ALKBH7 protein
ABH7 protein
SPATA11 protein
UNQ6002 protein
PRO34564 protein

Information sourced from Uniprot.org

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