Human ALDOB protein (Recombinant) (His-Tag) (STJP017527)

Name: Human ALDOB protein (Recombinant) (His-Tag) (STJP017527)
SKU: STJP017527
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP017527

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Short Description	Recombinant-Human ALDOB-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	ALDOB
Gene ID	229
Uniprot ID	ALDOB_HUMAN
Accession Number	NP_000026.2
Immunogen	Human
Immunogen Region	1-364aa
Immunogen Sequence	MAHRFP ALTQEQKKEL SEIAQSIVAN GKGILAADES VGTMGNRLQR IKVENTEENR RQFREILFSV DSSINQSIGG VILFHETLYQ KDSQGKLFRN ILKEKGIVVG IKLDQGGAPL AGTNKETTIQ GLDGLSERCA QYKKDGVDFG KWRAVLRIAD QCPSSLAIQE NANALARYAS ICQQNGLVPI VEPEVIPDGD HDLEHC

Function	Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check.
Protein Name	Fructose-Bisphosphate Aldolase B Liver-Type Aldolase
Database Links	Reactome: R-HSA-5657560 Reactome: R-HSA-70171 Reactome: R-HSA-70263 Reactome: R-HSA-70350
Cellular Localisation	Cytoplasm Cytosol Cytoskeleton Microtubule Organizing Center Centrosome Centriolar Satellite
Alternative Protein Names	Fructose-Bisphosphate Aldolase B protein Liver-Type Aldolase protein ALDOB protein ALDB protein

Information sourced from Uniprot.org