| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check. |
| Protein Name | Fructose-Bisphosphate Aldolase BLiver-Type Aldolase |
| Database Links | Reactome: R-HSA-5657560Reactome: R-HSA-70171Reactome: R-HSA-70263Reactome: R-HSA-70350 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonMicrotubule Organizing CenterCentrosomeCentriolar Satellite |
| Alternative ELISA Names | Fructose-Bisphosphate Aldolase B ELISA kitLiver-Type Aldolase ELISA kitALDOB ELISA kitALDB ELISA kit |
| output | |
Information sourced from Uniprot.org
