| Post Translational Modifications | Phosphorylated on tyrosine residues probably by SRC subfamily protein kinases.multiple phosphorylation is leading to dissociation from nuclear structures implicated in chromatin structural changes. |
| Function | Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation.the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3.in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation.the function probably implicates targeting of PKA to NFKB1. |
| Protein Name | A-Kinase Anchor Protein 8Akap-8A-Kinase Anchor Protein 95 KdaAkap 95 |
| Cellular Localisation | NucleusNucleus MatrixNucleolusCytoplasmAssociated With The Nuclear Matrix In Interphase And Redistributes Mostly To Chromatin At MitosisHoweverMitotic Chromatin Localization Has Been QuestionedUpon Nuclear Reassembly At The End Of MitosisIs Sequestered Into The Daughter Nuclei Where It Re-Acquires An Interphase DistributionExhibits Partial Localization To The Nucleolus In InterphaseWhere It Colocalizes With Ubtf/UbfSuggesting Localization To The Fibrillary Center And/Or To The Dense Fibrillary ComponentColocalizes With Gja1 At The Nuclear Membrane Specifically During Cell Cycle G1/S Phase |
| Alternative Protein Names | A-Kinase Anchor Protein 8 proteinAkap-8 proteinA-Kinase Anchor Protein 95 Kda proteinAkap 95 proteinAKAP8 proteinAKAP95 protein |
Information sourced from Uniprot.org
