Human AICL/CLEC2B protein (Recombinant) (His-Tag) (STJP018009)

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STJP018009
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AICL/CLEC2B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2M uREA, 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLEC2B
Gene ID: 9976
Uniprot ID: CLC2B_HUMAN
Immunogen Region: 26-149aa
Accession Number: NP_005118
Immunogen: Human
Immunogen Sequence: KLTRDSQ SLCPYDWIGF QNKCYYFSKE EGDWNSSKYN CSTQHADLTI IDNIEEMNFL RRYKCSSDHW IGLKMAKNRT GQWVDGATFT KSFGMRGSEG CAYLSDDGAA TARCYTERKW ICRKRIH
Tissue Specificity Expressed preferentially in lymphoid tissues, and in most hematopoietic cell types.
Post Translational Modifications (Microbial infection) Ubiquitinated by human herpesvirus 8 protein K5, leading to endolysosomal degradation. N-linked glycosylated.required to enable surface expression and the extent of surface expression correlates with the number of functional conventional N-glycosylation sites.
Function Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells.
Protein Name C-Type Lectin Domain Family 2 Member B
Activation-Induced C-Type Lectin
C-Type Lectin Superfamily Member 2
Ifn-Alpha-2b-Inducing-Related Protein 1
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Golgi Apparatus Membrane
Resting Nk Cells Contain Intracellular Stores Of Clec2b Associated With The Golgi Complex
Alternative Protein Names C-Type Lectin Domain Family 2 Member B protein
Activation-Induced C-Type Lectin protein
C-Type Lectin Superfamily Member 2 protein
Ifn-Alpha-2b-Inducing-Related Protein 1 protein
CLEC2B protein
AICL protein
CLECSF2 protein
IFNRG1 protein

Information sourced from Uniprot.org

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