Human AICDA protein (Recombinant) (N-His) (STJP005971)

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STJP005971
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AICDA-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AICDA
Gene ID: 57379
Uniprot ID: AICDA_HUMAN
Immunogen Region: Gly23-Leu183
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity. Probably monoubiquitinated on several residues by RNF126.
Function Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Protein Name Single-Stranded Dna Cytosine Deaminase
Activation-Induced Cytidine Deaminase
Aid
Cytidine Aminohydrolase
Database Links Reactome: R-HSA-9821002
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Predominantly Cytosolic
In The Presence Of Mcm3ap/Ganp
Relocalizes To The Nucleus
Alternative Protein Names Single-Stranded Dna Cytosine Deaminase protein
Activation-Induced Cytidine Deaminase protein
Aid protein
Cytidine Aminohydrolase protein
AICDA protein
AID protein

Information sourced from Uniprot.org

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