Human AGXT2 protein (Recombinant) (N-His) (STJP005955)

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STJP005955
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AGXT2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AGXT2
Gene ID: 64902
Uniprot ID: AGT2_HUMAN
Immunogen Region: Cys259-Lys514
Immunogen: Homo sapiens (Human)
Function Multifunctional aminotransferase with a broad substrate specifcity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
Protein Name Alanine--Glyoxylate Aminotransferase 2 - Mitochondrial
Agt 2
(R-3-Amino-2-Methylpropionate--Pyruvate Transaminase
Beta-Alaat Ii
Beta-Alanine-Pyruvate Aminotransferase
D-3-Aminoisobutyrate-Pyruvate Aminotransferase
D-Aibat
D-Beta-Aminoisobutyrate-Pyruvate Aminotransferase
Database Links Reactome: R-HSA-389661
Reactome: R-HSA-73621
Cellular Localisation Mitochondrion
Alternative Protein Names Alanine--Glyoxylate Aminotransferase 2 - Mitochondrial protein
Agt 2 protein
(R-3-Amino-2-Methylpropionate--Pyruvate Transaminase protein
Beta-Alaat Ii protein
Beta-Alanine-Pyruvate Aminotransferase protein
D-3-Aminoisobutyrate-Pyruvate Aminotransferase protein
D-Aibat protein
D-Beta-Aminoisobutyrate-Pyruvate Aminotransferase protein
AGXT2 protein
AGT2 protein

Information sourced from Uniprot.org

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