Human AFAP protein (Recombinant) (His-Tag) (STJP018789)

Name: Human AFAP protein (Recombinant) (His-Tag) (STJP018789)
SKU: STJP018789
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP018789

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Short Description	Recombinant-Human AFAP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE/Denatured
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	AFAP1
Gene ID	60312
Uniprot ID	AFAP1_HUMAN
Accession Number	AAH32777.1
Immunogen	Human
Immunogen Region	250-590aa
Immunogen Sequence	GCSGPVDSE CPPPPSSPVH KAELEKKLSS ERPSSDGEGV VENGITTCNG KEQVKRKKSS KSEAKGTVSK VTGKKITKII SLGKKKPSTD EQTSSAEEDV PTCGYLNVLS NSRWRERWCR VKDNKLIFHK DRTDLKTHIV SIPLRGCEVI PGLDCKHPLT FRLLRNGQEV AVLEASSSED MGRWIGILLA ETGSSTDPEA LHYDYI

Tissue Specificity	Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma.
Post Translational Modifications	Phosphorylated on tyrosine residues by SRC.
Function	Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.
Protein Name	Actin Filament-Associated Protein 1 110 Kda Actin Filament-Associated Protein Afap-110
Database Links
Cellular Localisation	Cytoplasm Cytoskeleton Stress Fiber
Alternative Protein Names	Actin Filament-Associated Protein 1 protein 110 Kda Actin Filament-Associated Protein protein Afap-110 protein AFAP1 protein AFAP protein

Information sourced from Uniprot.org