Human AES protein (Recombinant) (His-Tag) (STJP017091)

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STJP017091
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AES-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: TLE5
Gene ID: 166
Uniprot ID: TLE5_HUMAN
Immunogen Region: 1-197aa
Accession Number: NP_001121
Immunogen: Human
Immunogen Sequence: MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK NGHDGDTHQE DDGEKSD
Tissue Specificity Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.
Post Translational Modifications Ubiquitinated by XIAP/BIRC4.
Function Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
Protein Name Tle Family Member 5
Amino-Terminal Enhancer Of Split
Amino Enhancer Of Split
Gp130-Associated Protein Gam
Grg-5
Groucho-Related Protein 5
Protein Esp1
Protein Grg
Tle Family Member 5 - Transcriptional Modulator
Database Links Reactome: R-HSA-4641265
Cellular Localisation Nucleus
Alternative Protein Names Tle Family Member 5 protein
Amino-Terminal Enhancer Of Split protein
Amino Enhancer Of Split protein
Gp130-Associated Protein Gam protein
Grg-5 protein
Groucho-Related Protein 5 protein
Protein Esp1 protein
Protein Grg protein
Tle Family Member 5 - Transcriptional Modulator protein
TLE5 protein
AES protein
GRG protein
GRG5 protein

Information sourced from Uniprot.org

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