Human ADH5 protein (Recombinant) (His-Tag) (STJP017594)

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STJP017594
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ADH5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 20% Glycerol 0.1M Nacl, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADH5
Gene ID: 128
Uniprot ID: ADHX_HUMAN
Immunogen Region: 1-374aa
Accession Number: NP_000662
Immunogen: Human
Immunogen Sequence: MANEVI KCKAAVAWEA GKPLSIEEIE VAPPKAHEVR IKIIATAVCH TDAYTLSGAD PEGCFPVILG HEGAGIVESV GEGVTKLKAG DTVIPLYIPQ CGECKFCLNP KTNLCQKIRV TQGKGLMPDG TSRFTCKGKT ILHYMGTSTF SEYTVVADIS VAKIDPLAPL DKVCLLGCGI STGYGAAVNT AKLEPGSVCA VFGLGG
Function Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation.
Protein Name Alcohol Dehydrogenase Class-3
Alcohol Dehydrogenase 5
Alcohol Dehydrogenase Class Chi Chain
Alcohol Dehydrogenase Class-Iii
Glutathione-Dependent Formaldehyde Dehydrogenase
Faldh
Fdh
Gsh-Fdh
S-(Hydroxymethylglutathione Dehydrogenase
Database Links Reactome: R-HSA-71384
Cellular Localisation Cytoplasm
Alternative Protein Names Alcohol Dehydrogenase Class-3 protein
Alcohol Dehydrogenase 5 protein
Alcohol Dehydrogenase Class Chi Chain protein
Alcohol Dehydrogenase Class-Iii protein
Glutathione-Dependent Formaldehyde Dehydrogenase protein
Faldh protein
Fdh protein
Gsh-Fdh protein
S-(Hydroxymethylglutathione Dehydrogenase protein
ADH5 protein
ADHX protein
FDH protein

Information sourced from Uniprot.org

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