Human Adenylate kinase 2 protein (Recombinant) (His-Tag) (STJP016412)

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STJP016412
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Host: E.coli
Applications: SDS-PAGE/Enzyme Activity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Adenylate kinase 2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) containing 2mM DTT, 20% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity: Specific activity is > 25unit/mg. One unit will convert 2.0 umoles of ADP to ATP + AMP per minute at pH 7.5 at 37C.
Gene Symbol: AK2
Gene ID: 204
Uniprot ID: KAD2_HUMAN
Immunogen Region: 1-239aa
Accession Number: NP_001616.1
Immunogen: Human
Immunogen Sequence: MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML RAMVASGSEL GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG FPRTVRQAEM LDDLMEKRKE KLDSVIEFSI PDSLLIRRIT GRLIHPKSGR SYHEEFNPPK EPMKDDITGE PLIRRSDDNE KALKIRLQAY HTQTTPLIEY YRKRGI
Tissue Specificity Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).
Function Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Protein Name Adenylate Kinase 2 - Mitochondrial
Ak 2
Atp-Amp Transphosphorylase 2
Atp -Amp Phosphotransferase
Adenylate Monophosphate Kinase Cleaved Into - Adenylate Kinase 2 - Mitochondrial - N-Terminally Processed
Database Links Reactome: R-HSA-499943
Cellular Localisation Mitochondrion Intermembrane Space
Alternative Protein Names Adenylate Kinase 2 - Mitochondrial protein
Ak 2 protein
Atp-Amp Transphosphorylase 2 protein
Atp -Amp Phosphotransferase protein
Adenylate Monophosphate Kinase Cleaved Into - Adenylate Kinase 2 - Mitochondrial - N-Terminally Processed protein
AK2 protein
ADK2 protein

Information sourced from Uniprot.org

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