| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human ACTN2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | ACTN2 |
| Gene ID: | 88 |
| Uniprot ID: | ACTN2_HUMAN |
| Immunogen Region: | Lys509-Leu894 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Ubiquitinated by FBXL22, leading to proteasomal degradation. |
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Protein Name | Alpha-Actinin-2Alpha-Actinin Skeletal Muscle Isoform 2F-Actin Cross-Linking Protein |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-373753Reactome: R-HSA-390522Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | CytoplasmMyofibrilSarcomereZ LineColocalizes With Myoz1 And Flnc At The Z-Lines Of Skeletal Muscle |
| Alternative Protein Names | Alpha-Actinin-2 proteinAlpha-Actinin Skeletal Muscle Isoform 2 proteinF-Actin Cross-Linking Protein proteinACTN2 protein |
Information sourced from Uniprot.org