| Function | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis. Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription. The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival. Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes. Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory. |
| Protein Name | Acetyl-Coenzyme A Synthetase - CytoplasmicAcetate--Coa LigaseAcetyl-Coa SynthetaseAcsAcecsAcetyl-Coa Synthetase 1Acecs1Acyl-Coa Synthetase Short-Chain Family Member 2Acyl-Activating EnzymePropionate--Coa Ligase |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-71384 |
| Cellular Localisation | CytoplasmCytosolNucleusGlucose Deprivation Results In Its Ampk-Dependent Phosphorylation And Subsequent Nuclear TranslocationPhosphorylation At Ser-659Leads To Exposure Of Its Nuclear Localization Signal Which Is Required For Its Interaction With Kpna1 And Subsequent Translocation To The NucleusFound In The Cytoplasm In Undifferentiated Neurons And Upon DifferentiationTranslocates To Nucleus |
| Alternative Protein Names | Acetyl-Coenzyme A Synthetase - Cytoplasmic proteinAcetate--Coa Ligase proteinAcetyl-Coa Synthetase proteinAcs proteinAcecs proteinAcetyl-Coa Synthetase 1 proteinAcecs1 proteinAcyl-Coa Synthetase Short-Chain Family Member 2 proteinAcyl-Activating Enzyme proteinPropionate--Coa Ligase proteinACSS2 proteinACAS2 protein |
Information sourced from Uniprot.org
