Function | Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient. |
Protein Name | Acetyl-Coenzyme A Synthetase 2-Like - MitochondrialAcetate--Coa Ligase 2Acetyl-Coa Synthetase 2Acecs2Acyl-Coa Synthetase Short-Chain Family Member 1Propionate--Coa Ligase |
Database Links | Reactome: R-HSA-71384 |
Cellular Localisation | Mitochondrion Matrix |
Alternative Protein Names | Acetyl-Coenzyme A Synthetase 2-Like - Mitochondrial proteinAcetate--Coa Ligase 2 proteinAcetyl-Coa Synthetase 2 proteinAcecs2 proteinAcyl-Coa Synthetase Short-Chain Family Member 1 proteinPropionate--Coa Ligase proteinACSS1 proteinACAS2L proteinKIAA1846 protein |
Information sourced from Uniprot.org