Human ACAT1 protein (Recombinant) (His-Tag) (STJP017908)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ACAT1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACAT1 |
| Gene ID | 38 |
| Uniprot ID | THIL_HUMAN |
| Accession Number | NP_000010 |
| Immunogen | Human |
| Immunogen Region | 34-427aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Succinylation at Lys-268, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5. |
| Function | This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. |
| Protein Name | Acetyl-Coa Acetyltransferase - MitochondrialAcetoacetyl-Coa ThiolaseT2 |
| Database Links | Reactome: R-HSA-70895Reactome: R-HSA-77108Reactome: R-HSA-77111Reactome: R-HSA-9837999Reactome: R-HSA-9854311Reactome: R-HSA-9915355 |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | Acetyl-Coa Acetyltransferase - Mitochondrial proteinAcetoacetyl-Coa Thiolase proteinT2 proteinACAT1 proteinACAT proteinMAT protein |
Information sourced from Uniprot.org