Human ABRAXAS2 protein (Recombinant) (N-His) (STJP016292)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ABRAXAS2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | ABRAXAS2 |
| Gene ID | 23172 |
| Uniprot ID | ABRX2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ile158 |
Additional Info
| Function | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1.deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage. |
| Protein Name | Brisc Complex Subunit Abraxas 2Abraxas Brother Protein 1Protein Fam175b |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonSpindle PoleA Minor Proportion Is Detected In The NucleusTranslocates Into The Nucleus In Response To Dna DamageDirectly Binds To Microtubules And Is Detected At The Minus End Of K-FibersCo-Localizes With Numa1 At Mitotic Spindle Poles |
| Alternative Protein Names | Brisc Complex Subunit Abraxas 2 proteinAbraxas Brother Protein 1 proteinProtein Fam175b proteinABRAXAS2 proteinABRO1 proteinFAM175B proteinKIAA0157 protein |
Information sourced from Uniprot.org