| Function | Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1.deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage. |
| Protein Name | Brisc Complex Subunit Abraxas 2Abraxas Brother Protein 1Protein Fam175b |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonSpindle PoleA Minor Proportion Is Detected In The NucleusTranslocates Into The Nucleus In Response To Dna DamageDirectly Binds To Microtubules And Is Detected At The Minus End Of K-FibersCo-Localizes With Numa1 At Mitotic Spindle Poles |
| Alternative Protein Names | Brisc Complex Subunit Abraxas 2 proteinAbraxas Brother Protein 1 proteinProtein Fam175b proteinABRAXAS2 proteinABRO1 proteinFAM175B proteinKIAA0157 protein |
Information sourced from Uniprot.org
