Name: Human ABCC6 (ATP Binding Cassette Transporter C6) Sandwich ELISA Kit Kit (STJE0006824)
SKU: STJE0006824
Availability: InStock

General Information
Product Properties
Target Information
Additional Info
Product Review

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.126ng/mL
Detection Limit:	0.312-20ng/mL
Short Description :	This ABCC6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	ABCC6
Gene ID:	368
Uniprot ID:	MRP6_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in kidney and liver. Very low expression in other tissues. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells and moderately in the adluminal compartment of the seminiferous tubules.
Post Translational Modifications	Glycosylated.
Function	Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.
Protein Name	Atp-Binding Cassette Sub-Family C Member 6 Anthracycline Resistance-Associated Protein Multi-Specific Organic Anion Transporter E Moat-E Multidrug Resistance-Associated Protein 6
Database Links	Reactome: R-HSA-382556 Reactome: R-HSA-5690338
Cellular Localisation	Basal Cell Membrane Multi-Pass Membrane Protein Localized To The Basal Membrane Of Sertoli Cells Isoform 1: Basolateral Cell Membrane Isoform 2: Endoplasmic Reticulum Membrane Single-Pass Membrane Protein
Alternative ELISA Names	Atp-Binding Cassette Sub-Family C Member 6 ELISA kit Anthracycline Resistance-Associated Protein ELISA kit Multi-Specific Organic Anion Transporter E ELISA kit Moat-E ELISA kit Multidrug Resistance-Associated Protein 6 ELISA kit ABCC6 ELISA kit ARA ELISA kit MRP6 ELISA kit
output

Information sourced from Uniprot.org

Model	Name	Reactivity	Application
STJE0006825	Mouse ABCC6 (ATP Binding Cassette Transporter C6) Sandwich ELISA Kit Kit (STJE0006825)	Mouse	ELISA
STJE0013200	Human ABCC6 (ATP Binding Cassette Transporter C6) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013200)	Human	ELISA
STJE0013201	Mouse ABCC6 (ATP Binding Cassette Transporter C6) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013201)	Mouse	ELISA
STJE0006821	Human ABCC3 (ATP Binding Cassette Transporter C3) Sandwich ELISA Kit Kit (STJE0006821)	Human	ELISA
STJE0006817	Human ABCC11 (ATP Binding Cassette Transporter C11) Sandwich ELISA Kit Kit (STJE0006817)	Human	ELISA

Human ABCC6 (ATP Binding Cassette Transporter C6) Sandwich ELISA Kit Kit (STJE0006824)

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