| Tissue Specificity | Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes. |
| Post Translational Modifications | N-glycosylated.leading to substrate-selective effects on its transport activity. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 4 Mrp/Cmoat-Related Abc TransporterMulti-Specific Organic Anion Transporter BMoat-BMultidrug Resistance-Associated Protein 4 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-382556Reactome: R-HSA-9748787Reactome: R-HSA-9753281 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneIts Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent |
| Alternative ELISA Names | Atp-Binding Cassette Sub-Family C Member 4 ELISA kitMrp/Cmoat-Related Abc Transporter ELISA kitMulti-Specific Organic Anion Transporter B ELISA kitMoat-B ELISA kitMultidrug Resistance-Associated Protein 4 ELISA kitABCC4 ELISA kitMOATB ELISA kitMRP4 ELISA kit |
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Information sourced from Uniprot.org
