| Function | ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes. |
| Protein Name | Mitochondrial Potassium Channel Atp-Binding SubunitAtp-Binding Cassette Sub-Family B Member 8 - MitochondrialAbcb8Mitochondrial Atp-Binding Cassette 1M-Abc1Mitochondrial Sulfonylurea-ReceptorMitosur |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Mitochondrial Potassium Channel Atp-Binding Subunit proteinAtp-Binding Cassette Sub-Family B Member 8 - Mitochondrial proteinAbcb8 proteinMitochondrial Atp-Binding Cassette 1 proteinM-Abc1 proteinMitochondrial Sulfonylurea-Receptor proteinMitosur proteinABCB8 proteinMABC1 proteinMITOSUR protein |
Information sourced from Uniprot.org
