| Post Translational Modifications | Hyperphosphorylated during the G1/S phase transition. |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. |
| Protein Name | Protein AatfApoptosis-Antagonizing Transcription FactorRb-Binding Protein Che-1 |
| Database Links | Reactome: R-HSA-193648 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Protein Names | Protein Aatf proteinApoptosis-Antagonizing Transcription Factor proteinRb-Binding Protein Che-1 proteinAATF proteinCHE1 proteinDED proteinHSPC277 protein |
Information sourced from Uniprot.org
