Human A1CF protein (Recombinant) (N-His) (STJP006064)

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STJP006064
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human A1CF-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: A1CF
Gene ID: 29974
Uniprot ID: A1CF_HUMAN
Immunogen Region: Gly389-Arg587
Immunogen: Homo sapiens (Human)
Function Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
Protein Name Apobec1 Complementation Factor
Apobec1-Stimulating Protein
Database Links Reactome: R-HSA-72200
Reactome: R-HSA-75094
Cellular Localisation Nucleus
Endoplasmic Reticulum
Cytoplasm
Predominantly Nuclear Where It Localizes To Heterochromatin
Also Cytoplasmic Where It Is Found At The Outer Surface Of The Endoplasmic Reticulum
Shuttles Between The Nucleus And Cytoplasm
May Be Transported Into The Nucleus By The Nuclear Import Protein Tnpo2/Trn2 Or By Apobec1
Alternative Protein Names Apobec1 Complementation Factor protein
Apobec1-Stimulating Protein protein
A1CF protein
ACF protein
ASP protein

Information sourced from Uniprot.org

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