| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
GPIP137 Blocking Peptide is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
CAPRIN1 |
| Gene ID: |
4076 |
| Uniprot ID: |
CAPR1_HUMAN |
| Immunogen Region: |
200-250 |
| Immunogen: |
Synthetic peptide taken within amino acid region 200-250 on human Caprin 1 protein. |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS). |
| Function | mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. Binds directly and selectively to MYC and CCND2 mRNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. |
| Peptide Name | Caprin-1Cell Cycle-Associated Protein 1Cytoplasmic Activation- And Proliferation-Associated Protein 1Gpi-Anchored Membrane Protein 1Gpi-Anchored Protein P137Gpi-P137P137gpiMembrane Component Chromosome 11 Surface Marker 1Rna Granule Protein 105 |
| Cellular Localisation | CytoplasmCytoplasmic Ribonucleoprotein GranuleCytosolCell ProjectionDendriteLamellipodiumMediates Formation And Localizes To Cytoplasmic Ribonucleoprotein Membraneless CompartmentsAssociated With Rna GranulesAt The Leading Edge Of Migrating FibroblastsColocalizes With Ddx3x |
| Alternative Peptide Names | Caprin-1 proteinCell Cycle-Associated Protein 1 proteinCytoplasmic Activation- And Proliferation-Associated Protein 1 proteinGpi-Anchored Membrane Protein 1 proteinGpi-Anchored Protein P137 proteinGpi-P137 proteinP137gpi proteinMembrane Component Chromosome 11 Surface Marker 1 proteinRna Granule Protein 105 proteinCAPRIN1 proteinGPIAP1 proteinGPIP137 proteinM11S1 proteinRNG105 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
