GPCR GPR75 Blocking Peptide peptide (STJ504158)

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STJ504158-250
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : GPCR GPR75 Blocking Peptide is synthetically produced from the 1-50 aa sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GPR75
Gene ID: 10936
Uniprot ID: GPR75_HUMAN
Immunogen Region: 1-50 aa
Immunogen: Synthetic peptide taken within amino acid reigon 1-50 on human G protein-coupled receptor 75 protein.
Tissue Specificity Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).
Function G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Peptide Name Probable G-Protein Coupled Receptor 75
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Probable G-Protein Coupled Receptor 75 protein
GPR75 protein

Information sourced from Uniprot.org

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