| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Glutamate Receptor 1 Blocking Peptide is synthetically produced from the 850-950 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
GRIA1 |
| Gene ID: |
2890 |
| Uniprot ID: |
GRIA1_HUMAN |
| Immunogen Region: |
850-950 |
| Immunogen: |
Synthetic peptide taken within amino acid reigon 850-950. |
| Tissue Specificity | Widely expressed in brain. |
| Post Translational Modifications | Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2. Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation. |
| Function | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
| Peptide Name | Glutamate Receptor 1Glur-1Ampa-Selective Glutamate Receptor 1Glur-AGlur-K1Glutamate Receptor Ionotropic - Ampa 1Glua1 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-399710Reactome: R-HSA-399719Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-5694530Reactome: R-HSA-8849932Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembranePostsynaptic Cell MembranePostsynaptic Density MembraneCell ProjectionDendriteDendritic SpineEarly Endosome MembraneRecycling Endosome MembranePresynapseSynapseInteraction With Cacng2Cnih2 And Cnih3 Promotes Cell Surface ExpressionColocalizes With Pdlim4 In Early EndosomesDisplays A Somatodendritic Localization And Is Excluded From Axons In NeuronsLocalized To Cone Photoreceptor Pedicles |
| Alternative Peptide Names | Glutamate Receptor 1 proteinGlur-1 proteinAmpa-Selective Glutamate Receptor 1 proteinGlur-A proteinGlur-K1 proteinGlutamate Receptor Ionotropic - Ampa 1 proteinGlua1 proteinGRIA1 proteinGLUH1 proteinGLUR1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
