| Tissue Specificity | Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues. |
| Function | Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate. |
| Peptide Name | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 8Glucose Transporter Type 8Glut-8Glucose Transporter Type X1 |
| Database Links | Reactome: R-HSA-189200Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembranePrincipally IntracellularMay Move Between Intracellular Vesicles And The Plasma MembraneThe Dileucine Internalization Motif Is Critical For Intracellular Sequestration |
| Alternative Peptide Names | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 8 proteinGlucose Transporter Type 8 proteinGlut-8 proteinGlucose Transporter Type X1 proteinSLC2A8 proteinGLUT8 proteinGLUTX1 protein |
Information sourced from Uniprot.org
