| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | GFRA-1-protein was developed from. For use in research applications. |
| Formulation: | PBS pH 7.4 |
| Purification: | Purified by Ni-affinity chromatography and gel-filtration from serum-free CHO growth media |
| Concentration: | 0.9 mg/ml |
| Storage Instruction: | Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
| Gene Symbol: | GFRA1 |
| Gene ID: | 2674 |
| Uniprot ID: | GFRA1_HUMAN |
| Function | Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-1 Gdnf Receptor Alpha-1 Gdnfr-Alpha-1 Gfr-Alpha-1 Ret Ligand 1 Tgf-Beta-Related Neurotrophic Factor Receptor 1 |
| Database Links | Reactome: R-HSA-419037 Reactome: R-HSA-5673001 Reactome: R-HSA-8853659 Reactome: R-HSA-9830674 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Golgi Apparatus Trans-Golgi Network Endosome Multivesicular Body Localizes Mainly To The Plasma Membrane In The Presence Of Sorl1 Shifts To Vesicular Structures Including Trans-Golgi Network Endosomes And Multivesicular Bodies |
| Alternative Protein Names | Gdnf Family Receptor Alpha-1 protein Gdnf Receptor Alpha-1 protein Gdnfr-Alpha-1 protein Gfr-Alpha-1 protein Ret Ligand 1 protein Tgf-Beta-Related Neurotrophic Factor Receptor 1 protein GFRA1 protein GDNFRA protein RETL1 protein TRNR1 protein |
Information sourced from Uniprot.org