GDNF protein (STJP000148)

SKU:
STJP000148-50

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Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: GDNF-protein was developed from. For use in research applications.
Formulation: PBS pH 7.4
Purification: Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media. Protein is sterile-filtrated through 0.22 µm filter
Concentration: 0.96 mg/ml
Storage Instruction: Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Gene Symbol: GDNF
Gene ID: 2668
Uniprot ID: GDNF_HUMAN
Tissue Specificity In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change.
Function Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Protein Name Glial Cell Line-Derived Neurotrophic Factor
Hgdnf
Astrocyte-Derived Trophic Factor
Atf
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Cellular Localisation Secreted
Alternative Protein Names Glial Cell Line-Derived Neurotrophic Factor protein
Hgdnf protein
Astrocyte-Derived Trophic Factor protein
Atf protein
GDNF protein

Information sourced from Uniprot.org

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