| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | GDNF-protein was developed from. For use in research applications. |
| Formulation: | PBS pH 7.4 |
| Purification: | Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media. Protein is sterile-filtrated through 0.22 µm filter |
| Concentration: | 0.96 mg/ml |
| Storage Instruction: | Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles |
| Gene Symbol: | GDNF |
| Gene ID: | 2668 |
| Uniprot ID: | GDNF_HUMAN |
| Tissue Specificity | In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. |
| Function | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor. Involved in the development of the neural crest. |
| Protein Name | Glial Cell Line-Derived Neurotrophic Factor Hgdnf Astrocyte-Derived Trophic Factor Atf |
| Database Links | Reactome: R-HSA-419037 Reactome: R-HSA-5673001 Reactome: R-HSA-8853659 Reactome: R-HSA-9830674 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Glial Cell Line-Derived Neurotrophic Factor protein Hgdnf protein Astrocyte-Derived Trophic Factor protein Atf protein GDNF protein |
Information sourced from Uniprot.org