FAM38A Blocking Peptide peptide (STJ504063)

SKU:
STJ504063-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: FAM38A Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PIEZO1
Gene ID: 9780
Uniprot ID: PIEZ1_HUMAN
Immunogen: Synthetic peptide taken between TMD14 and TMD15 on human FAM38A protein.
Tissue Specificity Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level). Expressed in myoblasts (at protein level).
Function Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation.
Peptide Name Piezo-Type Mechanosensitive Ion Channel Component 1
Membrane Protein Induced By Beta-Amyloid Treatment
Mib
Protein Fam38a
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Cell Membrane
Cell Projection
Lamellipodium Membrane
In Erythrocytes
Located In The Plasma Membrane
Accumulates At The Leading Apical Lamellipodia Of Endothelial Cells In Response To Shear Stress
Colocalizes With F-Actin And Myh9 At The Actomyosin Cortex In Myoblasts
Alternative Peptide Names Piezo-Type Mechanosensitive Ion Channel Component 1 protein
Membrane Protein Induced By Beta-Amyloid Treatment protein
Mib protein
Protein Fam38a protein
PIEZO1 protein
FAM38A protein
KIAA0233 protein

Information sourced from Uniprot.org

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