| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ENT1 Blocking Peptide for STJ500884 is synthetically produced from the 410-460 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Slc29a1 |
| Gene ID: |
63959 |
| Uniprot ID: |
S29A1_MOUSE |
| Immunogen Region: |
410-460 |
| Specificity: |
This blocking peptide is recommended for use in combination with ENT1 antibody, STJ500884 |
| Immunogen: |
Synthetic peptide taken within amino acid reigon 410-460 on mouse Equilibrative nitrobenzylthioinosine-sensitive nucleoside transporter ENT1 protein. |
| Tissue Specificity | Highly expressed in heart, spleen, lung, liver and testis. Lower level of expression in brain and kidney. Expressed in adipose tissues, brown adipocytes expressing significantly higher amounts than white adipocytes. Expressed in seminiferous tubules. |
| Post Translational Modifications | Glycosylated. |
| Function | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter. Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine. Also transports purine (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier. Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure. |
| Peptide Name | Equilibrative Nucleoside Transporter 1Ment1Equilibrative Nitrobenzylmercaptopurine Riboside-Sensitive Nucleoside TransporterEquilibrative Nbmpr-Sensitive Nucleoside TransporterNucleoside Transporter - Es-TypeSolute Carrier Family 29 Member 1 |
| Database Links | Reactome: R-MMU-83936Reactome: -MMU-9748787Reactome: -MMU-9755088 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCell Membrane |
| Alternative Peptide Names | Equilibrative Nucleoside Transporter 1 proteinMent1 proteinEquilibrative Nitrobenzylmercaptopurine Riboside-Sensitive Nucleoside Transporter proteinEquilibrative Nbmpr-Sensitive Nucleoside Transporter proteinNucleoside Transporter - Es-Type proteinSolute Carrier Family 29 Member 1 proteinSlc29a1 proteinEnt1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
