EAAT1 Blocking Peptide peptide (STJ503991)

SKU:
STJ503991-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: EAAT1 Blocking Peptide is synthetically produced from the 475-550 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Slc1a3
Gene ID: 20512
Uniprot ID: EAA1_MOUSE
Immunogen Region: 475-550
Immunogen: Synthetic peptide taken wtihin amino acid region 475-550 on mouse EAAT1 protein.
Tissue Specificity Detected in brain, in Bergmann glia arborising into the molecular layer of the cerebellum (at protein level). Localized in brain and is highly enriched in the Purkinje cell layer in cerebellum. Intermediate level in lung, low level in spleen, skeletal muscle and testis.
Post Translational Modifications Glycosylated.
Function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate.
Peptide Name Excitatory Amino Acid Transporter 1
Glial High Affinity Glutamate Transporter
High-Affinity Neuronal Glutamate Transporter
Glut-1
Sodium-Dependent Glutamate/Aspartate Transporter 1
Glast-1
Solute Carrier Family 1 Member 3
Database Links Reactome: R-MMU-210455
Reactome: -MMU-210500
Reactome: -MMU-425393
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Excitatory Amino Acid Transporter 1 protein
Glial High Affinity Glutamate Transporter protein
High-Affinity Neuronal Glutamate Transporter protein
Glut-1 protein
Sodium-Dependent Glutamate/Aspartate Transporter 1 protein
Glast-1 protein
Solute Carrier Family 1 Member 3 protein
Slc1a3 protein
Eaat1 protein
Gmt1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance