| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Dopamine Transporter Blocking Peptide is synthetically produced from the 550-600 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
SLC6A3 |
| Gene ID: |
6531 |
| Uniprot ID: |
SC6A3_HUMAN |
| Immunogen Region: |
550-600 |
| Immunogen: |
Synthetic peptide taken within amino acid region 550-600 on SLC6A3 protein. |
| Tissue Specificity | Highly expressed in substantia nigra. Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level). Expressed in the striatum (at protein level). |
| Function | Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling. |
| Peptide Name | Sodium-Dependent Dopamine TransporterDa TransporterDatSolute Carrier Family 6 Member 3 |
| Database Links | Reactome: R-HSA-379401Reactome: R-HSA-442660Reactome: R-HSA-5619081Reactome: R-HSA-5660724 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionNeuron ProjectionAxonLocalizes To Neurite Tips In Neuronal CellsColocalizes With Septin4 At Axon TerminalsEspecially At The Varicosities |
| Alternative Peptide Names | Sodium-Dependent Dopamine Transporter proteinDa Transporter proteinDat proteinSolute Carrier Family 6 Member 3 proteinSLC6A3 proteinDAT1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
