Dopamine Transporter Blocking Peptide peptide (STJ503947)

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STJ503947-250
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Short Description :Dopamine Transporter Blocking Peptide is synthetically produced from the 550-600 sequence and is suitable for use in western blot applications.
Applications:Immunodepletion/Immunocompetition
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation:Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol:SLC6A3
Gene ID:6531
Uniprot ID:SC6A3_HUMAN
Immunogen:Synthetic peptide taken within amino acid region 550-600 on SLC6A3 protein.
Immunogen Region:550-600
Tissue Specificity Highly expressed in substantia nigra. Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level). Expressed in the striatum (at protein level).
Function Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling.
Peptide Name Sodium-Dependent Dopamine Transporter
Da Transporter
Dat
Solute Carrier Family 6 Member 3
Database Links Reactome: R-HSA-379401
Reactome: R-HSA-442660
Reactome: R-HSA-5619081
Reactome: R-HSA-5660724
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Neuron Projection
Axon
Localizes To Neurite Tips In Neuronal Cells
Colocalizes With Septin4 At Axon Terminals
Especially At The Varicosities
Alternative Peptide Names Sodium-Dependent Dopamine Transporter protein
Da Transporter protein
Dat protein
Solute Carrier Family 6 Member 3 protein
SLC6A3 protein
DAT1 protein

Information sourced from Uniprot.org