| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Dopamine beta hydroxylase Positive Control for STJ507829 is synthetically produced from the 125-178 sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | Dbh |
| Gene ID: | 13166 |
| Uniprot ID: | DOPO_MOUSE |
| Immunogen Region: | 125-178 |
| Specificity: | This is positive control is recommended for use in combination with Dopamine beta hydroxylase antibody STJ507829. |
| Immunogen: | Synthetic peptide taken within amino acid region 125-178 on mouse Dopamine beta hydroxylase. |
| Post Translational Modifications | Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. N-glycosylated. |
| Function | Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. |
| Peptide Name | Dopamine Beta-HydroxylaseDopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase |
| Database Links | Reactome: R-MMU-209905 |
| Cellular Localisation | Soluble Dopamine Beta-Hydroxylase: Cytoplasmic VesicleSecretory Vesicle LumenCytoplasmic VesicleSecretory VesicleChromaffin Granule LumenSecretory Vesicle MembraneSingle-Pass Type Ii Membrane ProteinChromaffin Granule Membrane |
| Alternative Peptide Names | Dopamine Beta-Hydroxylase proteinDopamine Beta-Monooxygenase Cleaved Into - Soluble Dopamine Beta-Hydroxylase proteinDbh protein |
Information sourced from Uniprot.org