DOC2B Positive Control for STJ500788 peptide (STJ503980)

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STJ503980-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : DOC2B Positive Control for STJ500788 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Doc2b
Gene ID: 81820
Uniprot ID: DOC2B_RAT
Specificity: This is positive control is recommended for use in combination with DOC2B antibody STJ500788.
Tissue Specificity Expressed in brain.highly enriched in neurons.
Function Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.
Peptide Name Double C2-Like Domain-Containing Protein Beta
Doc2-Beta
Cellular Localisation Cytoplasm
Cytoplasmic Granule
Cell Membrane
Peripheral Membrane Protein
Translocates To The Plasma Membrane In A Calcium-Dependent Manner
Alternative Peptide Names Double C2-Like Domain-Containing Protein Beta protein
Doc2-Beta protein
Doc2b protein

Information sourced from Uniprot.org

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