| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
DOC2B Blocking Peptide for STJ500786 is synthetically produced from the 360-412 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Doc2b |
| Gene ID: |
81820 |
| Uniprot ID: |
DOC2B_RAT |
| Immunogen Region: |
360-412 |
| Specificity: |
This blocking peptide is recommended for use in combination with DOC2B antibody, STJ500786 |
| Immunogen: |
Synthetic Peptide taken within amino acid region 360-412 on DOC2b gene. |
| Tissue Specificity | Expressed in brain.highly enriched in neurons. |
| Function | Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes. |
| Peptide Name | Double C2-Like Domain-Containing Protein BetaDoc2-Beta |
| Cellular Localisation | CytoplasmCytoplasmic GranuleCell MembranePeripheral Membrane ProteinTranslocates To The Plasma Membrane In A Calcium-Dependent Manner |
| Alternative Peptide Names | Double C2-Like Domain-Containing Protein Beta proteinDoc2-Beta proteinDoc2b protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
