Dnmt3b Blocking Peptide for STJ506257 peptide (STJ506260)

Name: Dnmt3b Blocking Peptide for STJ506257 peptide (STJ506260)
SKU: STJ506260-250
Price: 312.6 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

STJ506260-250

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Short Description	Dnmt3b Blocking Peptide for STJ506257 is synthetically produced from the 50-100 sequence and is suitable for use in western blot applications.
Applications	Immunodepletion/Immunocompetition
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	Dnmt3b
Gene ID	13436
Uniprot ID	DNM3B_MOUSE
Immunogen Region	50-100
Specificity	This blocking peptide is recommended for use in combination with Dnmt3b antibody, STJ506257

Function	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells.
Peptide Name	Dna Cytosine-5-Methyltransferase 3b Dnmt3b Dna Methyltransferase Mmuiiib Dna Mtase Mmuiiib M.mmuiiib
Database Links	Reactome: R-MMU-212300 Reactome: -MMU-4655427
Cellular Localisation	Nucleus Accumulates In The Major Satellite Repeats At Pericentric Heterochromatin
Alternative Peptide Names	Dna protein Cytosine-5-Methyltransferase 3b protein Dnmt3b protein Dna Methyltransferase Mmuiiib protein Dna Mtase Mmuiiib protein M.mmuiiib protein Dnmt3b protein

Information sourced from Uniprot.org