Cynomolgus LILRA4/ILT-7/CD85g protein (Recombinant) (C-His) (STJP020304)

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STJP020304-100
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Short Description :Recombinant-Cynomolgus LILRA4/ILT-7/CD85g-C-His protein was developed in hek293 cells using the region Glu24-Asn446. For use in research applications.
Host:HEK293 cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:< 1 EU/Mu g of the protein by LAL method.
Immunogen:Recombinant Cynomolgus LILRA4/ILT-7/CD85g Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu24-Asn446) of Cynomolgus LILRA4/ILT-7/CD85g (Accession #) fused with His tag at the C-terminal.
Immunogen Region:Glu24-Asn446
Background LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades.

Information sourced from Uniprot.org

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