| Short Description : | Recombinant-Cynomolgus IL-31-N-His protein was developed in hek293 cells using the region Leu27-Thr163. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen: | Recombinant Cynomolgus IL-31 Protein is expressed from Expi293 with His tag at the N-terminal.；It contains Leu27-Thr163. |
| Immunogen Region: | Leu27-Thr163 |
| Background | Many autoimmune skin diseases, such as bullous pemphigoid (BP) , psoriasis and certain types of chronic urticaria, are associated with intensive pruritus. While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses. IL-31 was originally shown to be produced by activated helper T cells, particularly Th2 cells, mast cells, macrophages and dendritic cells. |
Information sourced from Uniprot.org