| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen Region: | Gly17-Gln208 |
| Immunogen: | Recombinant Cynomolgus Fc gamma RIII/CD16 Protein is expressed from Expi293 with His tag at the C-terminal.；It contains Gly17-Gln208. |
| Immunogen Sequence: | GMRAEDLPKAVVFLEPQWYR VLEKDRVTLKCQGAYSPEDN STRWFHNESLISSQTSSYFI AAARVNNSGEYRCQTSLSTL SDPVQLEVHIGWLLLQAPRW VFKEEESIHLRCHSWKNTLL HKVTYLQNGKGRKYFHQNSD FYIPKATLKDSGSYFCRGLI GSKNVSSETVNITITQDLAV SSISSFFPPGYQ |
| Background | Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set. |
Information sourced from Uniprot.org
