| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen Region: | Ser18-Gly287 |
| Immunogen: | Recombinant Cynomolgus CRTAM/CD355 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser18-Gly287) of Cynomolgus CRTAM/CD355 (Accession #) fused with hFc tag at the C-terminal. |
| Immunogen Sequence: | SLTNHTETITVEEGQTLTLK CVTSLRKSSSLQWLTPSGFT IFLNEYPAFKNSRYQLLHHS ANQLSISVSNITLQDEGVYK CLHYSDSVSTKEVKVIVLAT PFKPILEASVIRKQNGEEHV VLMCSAMRSKPPPQITWLLG NGVEVSGGTHHEFETDGKKC NTTSTLIIHTYGKNSTVDCI IRHRGLQGRKLVAPFRFEDL VTDEETASDALERNSVSSQD PQQPTSTVSVMEDSSTLEI |
| Background | Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2) , is required for the efficient production of IL-17, IL-22, and IFN Gamma by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. |
Information sourced from Uniprot.org
